By Katriana Meiman Faculty Mentor: Dr. Laura Sipe Abstract Hypermobile Ehlers-Danlos syndrome (hEDS) and Hypermobility Spectrum Disorder (HSD) are disorders of connective tissue weakness with unclear, likely multifactorial mechanisms. This project assessed mast cells as a potential contributing factor due to their ability to induce connective tissue remodeling and the prevalence of mast cell hyperactivity…