Category: Chemistry and Physics
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Improved synthesis of indazole-based sulfonamides for use in treating Mycobacterium tuberculosis
By Jillian Pabalan Faculty Mentor: Davis Oldham Abstract Tuberculosis (TB) is a respiratory infection caused by Mycobacterium tuberculosis (MTB). Drug-resistant TB presents an ever-growing threat to global health, necessitating the development of new antitubercular drugs. MTB proliferation is facilitated in part by KasA, an enzyme critical to the formation of the bacterial cell wall; high-throughput…
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Temporal Analysis of Jurkat T-Lymphocyte Viability after Treatment with Proton Pump Inhibitors
By Kiara Clark Faculty Mentor: Dr. Randall Reif Abstract The efficacy of the proton pump inhibitors (PPI) omeprazole, esomeprazole, and dexlansoprazole in the promotion of cell death in Jurkat T-lymphocytes (human acute T-cell leukemia) was assessed through fluorescence spectroscopy. In a 6-well plate, cells were cultured in PPI-treated medium or with the control chemotherapeutic, doxorubicin.…
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Using Hubble Space Telescope Observations to Study Dark Matter Deficient Galaxies
By Grace Dulay Faculty Mentor: Dr. Matthew Fleenor Abstract Typical cold dark matter (CDM) models suggest that all galaxies form within a dark matter halo, thus suggesting that lower-mass galaxies have a higher dark matter content. However, recent studies of the radial velocities of NGC-1052 DF4 and NGC-1052 DF2, two low-mass galaxies, yield results that…
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Determining concentrations of various metals in Red Bull energy drink using ICP-AES
By Calleigh Keeley, Liv Ewing Faculty Mentor: Dr. Sarah Smith Abstract Energy drinks are popular beverages among college students and young adults across the country, but a lot of the ingredients present are unknown to the consumers. While caffeine and vitamin concentrations are stated on the ingredients label, other ingredients listed are not quantified on…
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Development of a method to analyze the effect of proton pump inhibitors on cancer cells
By Franco Trujillo Faculty Mentor: Randal Reif Abstract Cancer cells are known to acidify their tumor microenvironment through excessive use of their proton pumps as a result of their rapid metabolism. Cancer cells rely on proton pumps to maintain their inner pH levels; thus, by inhibiting their use, apoptosis may be induced. Dexlansoprazole is a…
